Catalogue Search | MBRL
نتائج البحث
MBRLSearchResults
وجه الفتاة! هناك خطأ ما.
أثناء محاولة إضافة العنوان إلى الرف ، حدث خطأ ما :( يرجى إعادة المحاولة لاحقًا!
-
الضبطالضبط
-
مُحَكَّمةمُحَكَّمة
-
مستوى القراءةمستوى القراءة
-
نوع المحتوىنوع المحتوى
-
السنةمن:-إلى:
-
المزيد من المرشحاتالمزيد من المرشحاتنوع العنصرلديه النص الكاملالموضوعالناشرالمصدرالمُهدياللغةمكان النشرالمؤلفينالموقع
منجز
مرشحات
إعادة تعيين
3
نتائج ل
"Mante, Harald"
صنف حسب:
Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy
بواسطة
Adame, Anthony
,
Rockenstein, Edward
,
Schmidhuber, Sabine
في
alpha-Synuclein - immunology
,
Animals
,
Astrocytes - cytology
2015
Multiple system atrophy (MSA) is a neurodegenerative disease characterized by parkinsonism, ataxia and dysautonomia. Histopathologically, the hallmark of MSA is the abnormal accumulation of alpha-synuclein (α-syn) within oligodendroglial cells, leading to neuroinflammation, demyelination and neuronal death. Currently, there is no disease-modifying treatment for MSA. In this sense, we have previously shown that next-generation active vaccination technology with short peptides, AFFITOPEs®, was effective in two transgenic models of synucleinopathies at reducing behavioral deficits, α-syn accumulation and inflammation.
In this manuscript, we used the most effective AFFITOPE® (AFF 1) for immunizing MBP-α-syn transgenic mice, a model of MSA that expresses α-syn in oligodendrocytes. Vaccination with AFF 1 resulted in the production of specific anti-α-syn antibodies that crossed into the central nervous system and recognized α-syn aggregates within glial cells. Active vaccination with AFF 1 resulted in decreased accumulation of α-syn, reduced demyelination in neocortex, striatum and corpus callosum, and reduced neurodegeneration. Clearance of α-syn involved activation of microglia and reduced spreading of α-syn to astroglial cells.
This study further validates the efficacy of vaccination with AFFITOPEs® for ameliorating the neurodegenerative pathology in synucleinopathies.
Journal Article
Brain Potentials in the Processing of Complex Sentences: An ERP Study of Control and Raising Constructions
بواسطة
Clahsen, Harald
,
Featherston, Samuel
,
Münte, Thomas F
في
Brain - physiology
,
control theory
,
event-related potentials
2000
In the present study we made use of Event-Related Potentials (ERPs) to examine raising and subject control constructions in German. Our most salient result is that the ERPs elicited at the empty subject position of a raising construction are clearly different from those elicited at the corresponding position of an otherwise identical subject control construction, the former producing a stronger P600. We argue that this result provides an electrophysiological correlate of the theoretical distinction between NP trace and PRO.
Journal Article